Endocrine Abstracts

Background: Glucocorticoids have pleiotropic metabolic functions and acute glucocorticoid excess causes dramatic disruption of human metabolism. Whether glucocorticoids exert adipose tissue depot-specific effects on the nontargeted metabolome in unknown.Aim: Assess the nontargeted metabolome in the systemic circulation and in femoral adipose tissue-specific blood samples in response to physiological hyperinsulinaemia and acute hypercortisolaemia.<p c...

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have...

Controversy exists as to the best way to determine which thyroid nodules we should have fine needle aspiration (FNA). The lack of consensus in the British and American Thyroid Association guidelines has not helped to clarify this. The use of ultrasound scan (USS) determined U grading versus a composite of nodule size and pre-determined number of suspicious features continues to be debated. We therefore set out to compare the accuracy of U grading with other identified USS feat...

Patients with diabetes mellitus (DM) type 2 is a group of high cardiovascular risk. The incidence of coronary heart disease in their 2–4 times higher than in the population without diabetes, 80% of cases of diabetes combined with hypertension. At the same time any change in lipid metabolism leads to increased cardiovascular risk in patients with type 2 diabetes. Statins is first-line drugs in patients with dyslipidemia.Materials and methods: The stu...

Today, there are 382 million people living with diabetes. The overwhelming majority have a type 2 diabetes. Metformin is first-line drug is for many of them.Materials and methods: The study involved 26 patients in mean age 54.46±1.2 years (from 41 to 65), among them, 14 women and 12 men. 21 patients with newly diagnosed diabetes and five patients receiving treatment with sulfonylureas. All patients were prescribed metformin in mean dose 2000 mg. Dur...

Background: In spite of being the most frequent genetic form of male hypogonadism, Klinefelter’s syndrome is not so rarely undiagnosed until adulthood. As the severity of manifestations in Klinefelter’s syndrome is proportional to the number of additional X chromosomes, they seem less severe and aparent in its classic form, with a 47,XXY karyotype than in cases of this syndrome with mosaicism and other variants.Case report: A 25-year-old male w...

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

Introduction: Adrenal pheochromocytomas are rare neuroendocrine tumours and their prevalence is likely underestimated – in some series 50% of cases were diagnosed during autopsy. The clinical presentation varies among patients which may make the diagnosis difficult to establish. We present the case of a woman with certain clinical characteristics of pheochromocytomas and who was diagnosed after having suffered a stroke. Specific points suggesting a pheochromocytoma and cr...

Background /aim: Osteoporosis is a generalized bone disease, characterized by impaired bone firmness, resulting in an increased predisposition for fractures. In order to detect the subjects at risk for fractures, one should actively search for them, primarily in a group of postmenopausal women, considering clinical risk factors. Apart from others, the relevant risk factors are lack of estrogen and low body mass index (BMI <19 kg/m2).: The aim of this study was t...

Context: Polycystic ovary syndrome (PCOS) is a very common endocrinopathy affecting approximately 6–18% of women of reproductive age. It is also the most common cause of infertility due to anovulation. PCOS is characterized by menstrual disorders, polycystic or enlarged ovaries on ultrasound, but hyperandrogenism is the central feature of PCOS. Assessing of serum testosterone level (T) or free T is recommended by the guidelines in the diagnosis of PCOS. Diagnostic value o...